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Last Updated: 06/03/2024
siRNA Larvicides for Control of Malaria Vector Mosquitoes
Objectives
To perform a high-throughput screen to identify small interfering (si)RNAs that cause death when ingested by mosquito larvae as a method for reducing malaria transmission. Malaria vector mosquitoes are developing resistance to current larval insecticides, which are used to complement other control strategies such as insecticide-treated nets. Small RNAs are ingested by mosquito larvae and can silence their gene targets. The team will perform a screen of siRNAs targeting 1000 candidate larval essential genes in the malaria vector mosquito Anopheles gambiae at different developmental stages. Identified lethal siRNAs will be tested in multiple Anopheline species to target malaria spread by other species.
Principal Institution
Principal Investigators / Focal Persons
External reference
Thematic Categories
Date
May 2015
Total Project Funding
$100,000
Funding Details
Project Site
Deep Dives
Related Resources
