Last Updated: 01/10/2025
Search for the master transcription factor in the male gametocyte of malaria parasites and elucidation of the male-specific gene regulation mechanism
Objectives
The aim of this study is to identify male-specific transcription factors that recruit molecules that interact with these factors to gene regulatory regions and analyze their functions to clarify the overall picture of the genetic control mechanism that induces the formation of male gametocytes.
The malaria parasite gametocyte is an important cellular stage in malaria transmission. The researchers have previously elucidated the genetic control mechanism that induces the differentiation of female gametocytes through studies of transcription factors in the rodent malaria parasite Plasmodium berghei, but the genetic control mechanism that induces the differentiation and formation of male gametocytes remains unknown. Recently, researchers have discovered chromatin remodeling factors essential for the formation of male gametocytes and revealed that they are directly involved in the transcription of male-specific genes.
Apr 2024 — Mar 2027
$30,900
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