Last Updated: 03/10/2025
Elucidation of the mechanism of formation and maintenance of malaria immune memory T cells using a virulent strain continuous infection model
Objectives
This study aims to elucidate the memory of T cell groups and their role in the establishment of host defense immunity against infection with highly virulent malaria parasites.
Human immunity against malaria is not lifelong like that against measles, and it takes repeated infections with the malaria parasite to finally acquire immunity to a degree that does not cause the disease. It is speculated that one of the reasons for this is that infection with highly virulent malaria parasites has a negative effect on the formation and maintenance of immune memory cells, but the factors and mechanisms involved in the formation and maintenance of immune memory cells in malaria are still shrouded in mystery. The principal investigator has previously elucidated the mechanism of T cell immune response, which plays an important role in defense against malaria infection.
Apr 2025 — Mar 2028
$30,892
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