Last Updated: 05/10/2023
Research and development on the molecular basis of an innovative malaria control strategy that achieves both treatment and radical cure
Objectives
To elucidate the molecular mechanism related to the regulation of the diapause stage, centering on SET-hyp, and reactivate (shock) the diapause stage parasites using histone methyltransferase inhibitors and transform them into red endotype parasites.
Malaria is still a raging infectious disease, and the recent corona crisis has various negative effects on malaria, so the WHO has reported an increase in the number of infected people and deaths. disease. Plasmodium falciparum and vivax malaria are the majority of malaria-infected people, and vivax malaria accounts for about half of epidemic areas other than Africa. This is an urgent issue. Due to the difficulty of establishing an experimental system for new drug development and vaccine development during the dormant period, which requires specialized measures against vivax malaria, the number of research institutions that can carry it out is extremely limited. The possibility of an innovative shock & kill treatment has never been attempted in the treatment of malaria. Consider the kill effect of Malaria is still a devastating disease, with more than 400,000 deaths and more than 200 million people infected each year. WHO expects the damage caused by malaria to expand, and it is a disease that requires further measures.
Apr 2021 — Mar 2024
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